Application of Cloud Point Method for Spectrophotometric Determination of Salbutamol Sulphate and Methyldopa
A simple and efficient cloud point spectrophotometric method has been used for the determination of
salbutamol sulphate andmethyldopa both in pure and pharmaceutical preparations.The procedurewas based
on the ion association formation with eosin Y. The extraction of ion association, drown to Triton X-114
micelles,wasmeasured spectrophotometrically. The phase separationwas studied and optimized.Beer's law
was rectilinear over the concentration ranges of 0.1-20 and 0.3-10 μg/mLwithmolar absorptivity 4x104 and
5.7x104 L.mol-1 cm-1 and average recovery 98.21% and 101.27% for the above drugs, respectively. The
method was applied successfully for the determination of salbutamol sulphate and methyldopa in
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