Electrochemical Determination of Furosemide Drug at Tranexamic Acid Gold Nanoparticles Modified Glassy Carbon Electrode
Abstract
The reported work discussed the simpler and sensitive strategy for the electrochemical
determination of furosemide by employed tranexamic acid derived gold nanoparticles modified
glassy carbon electrode (GCE). The synthesis of tranexamic acid derived gold nanoparticles (Tr-
AuNps) was carried out using single step approach. The synthesized Tr-AuNps were characterized
by using atomic force microscopy (AFM), illustrated that the particles are spherical in shape with
an average size of 35 nm. The synthesized AuNps have modified the sensing surface of GCE. The
modified GCE demonstrated highly catalytic behavior for the oxidation of loop diuretic drug
furosemide. The influence of pH and supporting electrolyte was examined and the working
conditions were optimized. The amperometric determination of furosemide was also carried out at
the Tr-AuNps modified GCE under stirred conditions using Britton Robinson buffer (BR buffer)
as supporting electrolyte at pH 5. The linear calibration plot showed the dependence of the peak
current on increasing concentrations of furosemide in the range of 50 μM to 500 μM furosemide
with the detection limit of 5 μM. The proposed sensing plan has been successfully employed for
the quantification of furosemide in human urine samples with satisfactory recoveries.
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